Published: Multi-omics profiling uncovers miRNA-guided molecular changes in SCI

I am thrilled to share that our new study, "Integrated multi-omics profiling uncovers miRNA-guided molecular changes in acute spinal cord injury," has just been published in Molecular Therapy: Nucleic Acids (MT-NA)!

What We Did & Why It Matters

• Approach: We applied an integrative multi-omics analysis (miRNA, mRNA, and proteomics) to samples from acute Spinal Cord Injury (SCI).
• Discovery: We successfully mapped the dynamic and coordinated molecular changes occurring across gene, miRNA, and protein levels post-injury.
• Key Finding: We identified several key miRNAs as central drivers of post-injury molecular reprogramming.
• Therapeutic Potential: Crucially, in vitro inhibition of miR-20a promoted neurogenesis-related responses, positioning it as a promising therapeutic target for SCI.

Publishing in MT-NA is a true honor. A heartfelt thanks to all co-authors, collaborators, and everyone who supported this challenging but rewarding journey.

I am excited to continue this work and explore how these findings can be translated into new treatments.

Read the full, open-access article here: doi:10.1016/j.omtn.2025.102746

#SpinalCordInjury #SCI #Neuroregeneration #miRNA #MultiOmics #MolecularTherapy #DrugDiscovery #OpenAccess #ScientificResearch