Research & Publications

My research focuses on understanding the molecular mechanisms underlying nervous system injuries. I apply advanced multi-omics profiling, machine learning, and single-cell transcriptomics to discover novel therapeutic targets for neuroregeneration. Below is a selected list of my peer-reviewed publications.

Neural stem cell-derived extracellular vesicles drive early neuroprotective and anti-apoptotic responses in spinal cord injury organotypic slices

Kristyna Sintakova, Vojtech Sprincl, Ivan Arzhanov, Ruslan Klassen, Lukas Valihrach, Nataliya Romanyuk

Frontiers in Cellular Neuroscience2026

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Inhibition of miR-20a promotes neural stem cell survival under oxidative stress conditions

Ivan Arzhanov, Ruslan Klassen, Lukas Valihrach, Nataliya Romanyuk

Frontiers in Neuroscience2025

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Integrated multi-omics profiling uncovers miRNA-guided regulatory networks after spinal cord injury in rats

Ruslan Klassen, Sarka Chytilova, Ivan Arzhanov, Daniel Zucha, Eva Rohlova, Peter Androvic, Pavel Abaffy, Lucia Urdzikova-Machova, Mikael Kubista, Nataliya Romanyuk, Lukas Valihrach

Molecular Therapy Nucleic Acids2025

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Recent advances in deciphering oligodendrocyte heterogeneity with single-cell transcriptomics

Lukas Valihrach, Zuzana Matusova, Daniel Zucha, Ruslan Klassen, Sarka Benesova, Pavel Abaffy, Mikael Kubista, Miroslava Anderova

Frontiers in Cellular Neuroscience2022

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Silver Nanoparticles Alter Microtubule Arrangement, Dynamics and Stress Phytohormone Levels

Jindřiška Angelini, Ruslan Klassen, Jitka Široká, Ondřej Novák, Kamil Záruba, Jakub Siegel, Zuzana Novotná, Olga Valentová

Plants2022

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Transient astrocyte‐like NG2 glia subpopulation emerges solely following permanent brain ischemia

Denisa Kirdajova, Lukas Valihrach, Martin Valny, Jan Kriska, Daniela Krocianova, Sarka Benesova, Pavel Abaffy, Daniel Zucha, Ruslan Klassen, Denisa Kolenicova, Pavel Honsa, Mikael Kubista, Miroslava Anderova

Glia2021

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